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The level of DHFR activity in the human liver is relatively low such that high levels of folic acid intake (such as by megadosing vitamins) can lead to pathological consequences

Currently, another small molecule GLP-1R agonist called compound 29 (DA-302168S) has also shown good therapeutic potential (Dong et al., 2025)

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Heavy metals and pesticides toxicity in agricultural soil and plants: Ecological risks and human health implications

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